Production of 6-Aminopenicillanic Acid in Immobilized Enzyme Reactor with Electrodialysis.

Continuous Production of 6-amino Penicillanic Acid (6-APA) by Agarose Immobilized Penicillin Acylase in a Packed Column Reactor

Penicillin acylase, an industrially important biocatalyst catalyzes the conversion of penicillins to 6-amino penicillanic acid (6-APA) which is the main precursor for the production of semi-synthetic -lactam antibiotics. The present work involves the continuous production of 6-APA in a packed column reactor by using agarose immobilized penicillin acylase as a block polymer. The strain Escherich...

Reactions of 6-aminopenicillanic acid with carbohydrates and related substances.

Enzymatic Flow Reactor for Immobilized Enzyme Processes

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Preparation of 7-aminocephalosporanic acid and 6-aminopenicillanic acid.

Acylation of 6-Aminopenicillanic Acid by Penicillium chrysogenum.

num deacylated phenoxymethylpenicillin about six times faster than benzylpenicillin to 6-aminopenicillanic acid (6-APA) (R. C. Erickson and R. E. Bennett, Bacteriol. Proc., p. 65, 1961; Erickson and Bennett, Appl. Microbiol. 13:738, 1965. This was observed with a penicillin-nonproducing strain, Wis 49408 (obtained from the University of Wisconsin), and with a penicillinproducing strain, P-5009 ...